Antipolyphosphate monoclonal antibodies derived from autoimmune mice
Autoimmune mice spontaneously produce antibodies against polyP. The 2 examples of anti-polyP monoclonal antibodies studied here not only bound to polyP with high affinity but also cross-reacted with DNA and heparin. Neither antibody protected against thrombosis in a mouse model, but they might have some utility for <i>in vitro</i> studies of polyP.
Authors
- Richard J. Travers (ORCID: https://orcid.org/0000-0002-6839-4996)
- A. J. Scott (ORCID: https://orcid.org/0000-0001-6719-0417)
- Stephanie A. Smith
- James H. Morrissey (ORCID: https://orcid.org/0000-0002-1570-1569)
- Josepha-Clara Sedzro (ORCID: https://orcid.org/0000-0001-6577-3029)
- Yuqi Wang (ORCID: https://orcid.org/0000-0002-9793-6002)
- Rachel Hemp
- Chase N Morse
Institutions
- University of Illinois Urbana-Champaign (US)
- University of Michigan (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.rpth.2024.102550
- Citations
- 2
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- Oklahoma Medical Research Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute