Targeted gene panel sequencing of liquid and tissue biopsies reveals actionable genomic alterations in Ghanaian metastatic breast cancer cases
Liquid biopsy detected multiple additional actionable variants in Ghanaian women with breast cancer. Plasma cfDNA analysis featured fewer variations in sample preparation which is a key consideration in resource-limited settings. Liquid biopsy presents a great opportunity to improve cancer care in Africa.
Authors
- David Hutchful (ORCID: https://orcid.org/0000-0002-3646-1736)
- Harry Akligoh (ORCID: https://orcid.org/0000-0002-6949-1392)
- Emmanuella Amoako (ORCID: https://orcid.org/0000-0002-2965-7597)
- Luke Adagrah Aniakwo
- Nicole Lim
- Setor Amuzu (ORCID: https://orcid.org/0000-0003-3244-7475)
- Joyce M. Ngoi (ORCID: https://orcid.org/0000-0003-1698-609X)
- Min‐Han Tan (ORCID: https://orcid.org/0000-0002-0644-3457)
- Yakubu Alhassan (ORCID: https://orcid.org/0000-0002-0658-3820)
- Patrick Kafui Akakpo (ORCID: https://orcid.org/0000-0003-0356-0663)
- Kofi Ulzen‐Appiah (ORCID: https://orcid.org/0000-0002-9872-9048)
- Yaw Bediako (ORCID: https://orcid.org/0000-0001-9786-7564)
- Lily Paemka (ORCID: https://orcid.org/0000-0001-7498-520X)
- Emmanuel Owusu Ofori (ORCID: https://orcid.org/0000-0002-3891-0849)
- Lisa Rajah
- Bashiro Jimah
- Emmanuel Kofi Quaye
- Barikisu Anna Ibrahim
- Ernest Amo Obeng
- Michelle Pek
- Randy Tackie
- Jack Challis
- Aida Manu (ORCID: https://orcid.org/0009-0003-9568-6702)
- Ganiyu Adebisi Rahman
Institutions
- University of Cape Coast (GH)
- University of Ghana (GH)
- Engineers Without Borders Canada (CA)
- Biotech Park (IN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1016/j.tranon.2024.102100
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- DST-NRF Centre Of Excellence In Tree Health Biotechnology