Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae
Pneumococcal clusters, both extracellular and intracellular, facilitate macrolide resistance acquisition, and ICEs were acquired at a higher frequency than the capsule locus. Metabolic changes could serve as intervention targets.
Authors
- Santiago M. Lattar (ORCID: https://orcid.org/0000-0001-5703-8024)
- Xueqing Wu (ORCID: https://orcid.org/0000-0001-8013-5770)
- Yunsong Yu (ORCID: https://orcid.org/0000-0003-2903-918X)
- Yih‐Ling Tzeng (ORCID: https://orcid.org/0000-0001-7950-8197)
- Babek Alibayov (ORCID: https://orcid.org/0009-0006-2085-6991)
- Lance E. Keller (ORCID: https://orcid.org/0000-0002-8779-9278)
- David S. Stephens (ORCID: https://orcid.org/0000-0002-8174-660X)
- Ana G. Jop Vidal (ORCID: https://orcid.org/0009-0005-0785-0889)
- D. Ashley Robinson (ORCID: https://orcid.org/0000-0002-6081-858X)
- Brenda S. Antezana (ORCID: https://orcid.org/0000-0002-2023-5240)
- Austin A. Medders (ORCID: https://orcid.org/0009-0006-2116-6052)
- Xi Xiang
- Jorge Eugenio Vidal (ORCID: https://orcid.org/0000-0003-0573-5658)
- Fuminori Sakai
Institutions
- Emory University (US)
- University of Mississippi Medical Center (US)
- Zhejiang University (CN)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1016/j.drup.2024.101138
- Citations
- 3
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Emory University
- Mississippi IDeA Network of Biomedical Research Excellence
- National Natural Science Foundation of China
- National Institutes of Health
- Centers for Disease Control and Prevention
- School of Medicine, Emory University
- National Institute of General Medical Sciences
- Natural Science Foundation of Zhejiang Province