Interdependence between myocardial deformation and perfusion in patients with T2DM and HFpEF: a feature-tracking and stress perfusion CMR study
Patients with T2DM and HFpEF exhibited significant LV systolic and diastolic deformation, decreased LA reservoir strain, severe impairment of myocardial perfusion, and elevated LA booster strain that is a compensatory response in HFpEF. Global MPRI was identified as an independent influencing factor on LA reservoir and LA booster strain. The difference in LA reservoir and LA booster strain between patients with T2DM with and without HFpEF was totally mediated by global MPRI, suggesting a possible mechanistic link between microcirculation impairment and cardiac dysfunction in diabetes. Myocardial perfusion and LA strain may prove valuable for diagnosing and managing HFpEF in the future.
Authors
- Xinni Li
- Wenkun Ma (ORCID: https://orcid.org/0000-0001-6196-7141)
- Sang Soo Kang (ORCID: https://orcid.org/0000-0001-9424-2067)
- Yuting Liu (ORCID: https://orcid.org/0000-0001-9175-514X)
- Chengxing Shen (ORCID: https://orcid.org/0000-0002-8286-5627)
- Dan Yang (ORCID: https://orcid.org/0009-0002-0103-7270)
- Huo-Yuan Xiao
- Jingwei Pan
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1186/s12933-024-02380-2
- Citations
- 5
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Science and Technology Innovation Plan Of Shanghai Science and Technology Commission