Successful EGFR Mutation Detection in Cytological Specimens of Lung Cancer with Challenging Biopsies by Integrating Virtual Bronchoscopy Navigation and Endobronchial Ultrasound Guidance with Highly Sensitive Next-Generation Sequencing: A Case Report
VBN-guided EBUS-GS brushing, a minimally invasive approach, combined with highly sensitive NGS has the potential to provide accurate molecular diagnoses to more patients with lung cancer, thereby offering opportunities for personalized treatment. Our findings warrant further investigation to determine optimal bronchoscopic technologies for obtaining tumor specimens.
Authors
- Ryosuke Ogata
- Takahiro Takazono (ORCID: https://orcid.org/0000-0002-0696-5386)
- Shinnosuke Takemoto (ORCID: https://orcid.org/0000-0003-0373-0618)
- Noriho Sakamoto (ORCID: https://orcid.org/0000-0002-7577-476X)
- Hirokazu Taniguchi (ORCID: https://orcid.org/0000-0003-2414-8344)
- Hiroko Hayashi (ORCID: https://orcid.org/0000-0003-0809-4032)
- Hiroshi Soda (ORCID: https://orcid.org/0000-0003-4993-1837)
- Hiroshi Mukae (ORCID: https://orcid.org/0000-0002-1429-5706)
- Hiroaki Senju
- Yasuhiro Umeyama
- Yuichi Fukuda
- M Iwanaga
Institutions
- Sasebo City General Hospital (JP)
- Senju Pharmaceutical (Japan) (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Case Reports in Oncology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1159/000540356
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00