Plasma apixaban concentrations and thrombin generation assay parameters in response to dose reduction for atrial fibrillation
Off-label underdosed apixaban resulted in lower apixaban concentrations than both on-label standard and reduced-dose regimens. A considerable proportion of the patients exhibited apixaban concentrations outside the expected range, suggesting the potential benefits of plasma concentration monitoring. Further studies are needed to compare dosages directly, investigate the impact of plasma apixaban concentration monitoring and validate the current dose-reduction criteria.
Authors
- JungMin Choi (ORCID: https://orcid.org/0000-0003-4633-640X)
- Muhan Yeo (ORCID: https://orcid.org/0000-0003-0751-2407)
- Eue‐Keun Choi (ORCID: https://orcid.org/0000-0002-0411-6372)
- Seil Oh (ORCID: https://orcid.org/0000-0002-2504-9615)
- Hyo‐Jeong Ahn (ORCID: https://orcid.org/0000-0003-3590-0378)
- So‐Ryoung Lee (ORCID: https://orcid.org/0000-0002-6351-5015)
- Soonil Kwon (ORCID: https://orcid.org/0000-0002-4791-6855)
- Hyoung‐Seob Park (ORCID: https://orcid.org/0000-0002-8042-1029)
- Hyun Kyung Kim (ORCID: https://orcid.org/0000-0002-2087-4851)
- Gregory Y. H. Lip
- Kyung‐Yeon Lee
Institutions
- Seoul National University (KR)
- University of Liverpool (GB)
- Seoul Metropolitan Government (KR)
- Seoul National University Hospital (KR)
- Liverpool Heart and Chest Hospital (GB)
- SNUH SMG-SNU Boramae Medical Center (KR)
- University College Hospital at Westmoreland Street (GB)
- Keimyung University Dongsan Medical Center (KR)
- University College London (GB)
- Keimyung University (KR)
- Liverpool John Moores University (GB)
- Aalborg University (DK)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1111/bcp.16211
- Citations
- 5
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Korea Medical Device Development Fund