Impact of Neoadjuvant Immunotherapy on Recurrence-Free Survival in Patients with High-Risk Localized HCC
Surgical resection for localized HCC is typically only reserved for those with solitary tumors without vascular invasion. In this retrospective analysis, we show that neoadjuvant immunotherapy may allow high-risk patients, including those who are outside of standard resection criteria, to undergo successful margin-negative resection and achieve comparable long-term clinical outcomes compared with upfront resection. These findings highlight need for prospective studies on neoadjuvant immunotherapy in HCC.
Authors
- Alexandra T. Strauss (ORCID: https://orcid.org/0000-0001-6313-7221)
- Tyrus Vong (ORCID: https://orcid.org/0000-0001-8133-9150)
- Robert P. Liddell (ORCID: https://orcid.org/0000-0002-9607-2484)
- Mari Nakazawa (ORCID: https://orcid.org/0000-0001-6055-8960)
- Kelvin Hong (ORCID: https://orcid.org/0000-0002-8420-5307)
- Robert A. Anders (ORCID: https://orcid.org/0000-0002-2363-9072)
- Kelly J. Lafaro (ORCID: https://orcid.org/0000-0002-7070-7269)
- Marina Baretti (ORCID: https://orcid.org/0000-0003-0125-2405)
- Richard A. Burkhart (ORCID: https://orcid.org/0000-0003-1087-0870)
- Won Jin Ho (ORCID: https://orcid.org/0000-0003-2644-5086)
- Christos Georgiades (ORCID: https://orcid.org/0000-0002-4559-1639)
- Amy K. Kim (ORCID: https://orcid.org/0000-0001-6121-9581)
- William R. Burns (ORCID: https://orcid.org/0000-0002-7634-9730)
- Jeffrey Meyer (ORCID: https://orcid.org/0000-0001-5116-5137)
- Paige Griffith
- Mike Fang (ORCID: https://orcid.org/0000-0002-8318-1016)
- Christopher R. Shubert (ORCID: https://orcid.org/0000-0001-6472-2350)
- Mark Yarchoan (ORCID: https://orcid.org/0000-0003-4401-0748)
- Jin Peng He (ORCID: https://orcid.org/0000-0001-9149-2247)
- Benjamin Philosophe (ORCID: https://orcid.org/0000-0003-3762-1559)
- Kiyoko Oshima (ORCID: https://orcid.org/0000-0002-3357-6247)
- Jane Zorzi
- Jacqueline Laurin
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0151
- Citations
- 8
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.96