Naldemedine-induced perforation of a diverticulum in the sigmoid colon of a patient with opioid-related constipation: a case report
These results suggest that the effects of OIC may have compressed the intestinal tract, which was followed by naldemedine-activation of peristalsis, which led to the onset of intestinal perforation. In patients with pre-existing diverticular disease, we should monitor for increased WBC counts and CRP levels after the initiation of treatment with naldemedine, and consider performing appropriate tests early in the event of abdominal complaints.
Authors
- Masafumi Kikuchi (ORCID: https://orcid.org/0000-0003-2148-6129)
- Mizuki Kobayashi (ORCID: https://orcid.org/0000-0002-4135-6789)
- Yumiko Akamine (ORCID: https://orcid.org/0000-0002-1346-757X)
- Tentaro Endo
- Hayato Yokota (ORCID: https://orcid.org/0000-0003-1389-435X)
- Takechiyo Yamada (ORCID: https://orcid.org/0000-0002-6910-3265)
- Takuro Kitabayashi
- Misato Horie
Institutions
- Akita University (JP)
- Akita University Hospital (JP)
Publication Details
- Journal
- Journal of Pharmaceutical Health Care and Sciences
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1186/s40780-024-00371-9
- Citations
- 3
- Primary Topic
- Diverticular Disease and Complications
- Type
- article
- Field-Weighted Citation Impact
- 1.72