Silvaticusins A–D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus
Three new ent-kaurane diterpenoids, silvaticusins A-C (1-3), along with a new ent-kaurane dimer silvaticusin D (4) were isolated from the aerial parts of Isodon silvaticus. The structures of these new compounds were established mainly by comprehensive analysis of their NMR and MS data. The absolute configuration of compounds 1 and 4 were determined using a single-crystal X-ray diffraction and computational methods, respectively. Compounds 2 and 3 were found to exhibit remarkable cytotoxic effects against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, and SW-480), with IC<sub>50</sub> values spanning from 1.27 ± 0.08 to 7.52 ± 0.33 μM.
Authors
- Xiao‐Nian Li
- Suping Chen (ORCID: https://orcid.org/0009-0004-3522-9291)
- Pema‐Tenzin Puno (ORCID: https://orcid.org/0000-0001-5212-3000)
- Hongping He (ORCID: https://orcid.org/0000-0002-7057-7687)
- Kun Hu (ORCID: https://orcid.org/0000-0001-9439-9670)
- Qi-Xiu Hai
- Yang-Yang Fu
- Han-Dong Sun
Institutions
- Kunming Institute of Botany (CN)
- Chinese Academy of Sciences (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Natural Products and Bioprospecting
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1007/s13659-024-00465-9
- Citations
- 8
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- Kunming Institute of Botany, Chinese Academy of Sciences
- Youth Innovation Promotion Association
- National Science Fund for Distinguished Young Scholars