Exploring the prognostic value of BRMS1 + microglia based on single-cell anoikis regulator patterns in the immunologic microenvironment of GBM
This pioneering study used NMF-based analysis to reveal the important predictive value of anoikis-regulated TME in GBM for prognosis and immunotherapeutic response. BRMS1 + microglial cells provide a new perspective for a deeper understanding of the immunosuppressive microenvironment of GBM and could serve as a potential therapeutic target in the future.
Authors
- Wei Ji
- Songyun Zhao (ORCID: https://orcid.org/0000-0003-0542-1085)
- Jiaheng Xie (ORCID: https://orcid.org/0000-0002-4992-498X)
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Pengpeng Zhang (ORCID: https://orcid.org/0000-0003-1488-265X)
- Ning Zhao (ORCID: https://orcid.org/0000-0001-7242-3262)
- Jinhui Liu (ORCID: https://orcid.org/0000-0001-8032-5099)
- Yuankun Liu (ORCID: https://orcid.org/0009-0009-3600-1586)
- Kaixiang Ni
- Chao Cheng (ORCID: https://orcid.org/0000-0002-9380-3296)
Institutions
- Jiangsu University (CN)
- Central South University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Jiangsu Province Hospital (CN)
- Wuxi People's Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1007/s11060-024-04781-5
- Citations
- 13
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.52