Dysregulated gene expression of SUMO machinery components induces the resistance to anti-PD-1 immunotherapy in lung cancer by upregulating the death of peripheral blood lymphocytes
Our findings implied that dysregulated gene expression of SUMO machinery components could induce the resistance of anti-PD-1 immunotherapy in lung cancer by upregulating the death of peripheral blood lymphocytes. These data might provide effective circulating biomarkers for predicting the efficacy of anti-PD-1 immunotherapy, and uncovered a novel regulatory mechanism of resistance to anti-PD-1 immunotherapy.
Authors
- Panyang Xu (ORCID: https://orcid.org/0000-0002-2895-9112)
- Jing Huang (ORCID: https://orcid.org/0000-0001-9820-7648)
- Yanyan Li (ORCID: https://orcid.org/0009-0005-7231-9293)
- Mengmeng Liu (ORCID: https://orcid.org/0000-0003-4422-7314)
- Yongsheng Zhang (ORCID: https://orcid.org/0009-0009-0714-3374)
- Ying Wang (ORCID: https://orcid.org/0000-0001-9263-1034)
- Chao Sun
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/fimmu.2024.1424393
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- People's Government of Jilin Province
- Jilin University
- First Hospital of Jilin University