Immune signaling pathways in Rhodnius prolixus in the context of Trypanosoma rangeli infection: cellular and humoral immune responses and microbiota modulation
<i>R. prolixus</i> recognizes <i>T. rangeli</i> infection and triggers humoral and cellular immune responses involving Toll pathway activation, <i>defensin C</i> synthesis, increased phenoloxidase activity, and enhanced hemocyte aggregation. On the other hand, <i>T. rangeli</i> infection suppressed some IMD pathway components, suggesting that, in <i>R. prolixus</i>, this pathway is involved in <i>defensins A</i> and <i>B</i> gene regulation. Importantly, these immune responses altered the bacterial microbiota composition, potentially favoring <i>T. rangeli</i> establishment in the insect vector.
Authors
- Cecília Stahl Vieira (ORCID: https://orcid.org/0000-0002-4130-4882)
- C.B. Mello (ORCID: https://orcid.org/0000-0002-0092-6829)
- Daniele P. Castro (ORCID: https://orcid.org/0000-0002-2827-6258)
- Suelen Bastos Pereira
- Patrı́cia Azambuja (ORCID: https://orcid.org/0000-0002-1405-8743)
- Débora Passos de Mattos
- Marcelo Salabert Gonzalez (ORCID: https://orcid.org/0000-0002-5442-6440)
Institutions
- Universidade Federal Fluminense (BR)
- Charles University (CZ)
- Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/fphys.2024.1435447
- Citations
- 3
- Primary Topic
- Insect symbiosis and bacterial influences
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação Oswaldo Cruz