Modulating neuroinflammation and cognitive function in postoperative cognitive dysfunction via <scp>CCR5</scp>‐<scp>GPCRs</scp>‐Ras‐<scp>MAPK</scp> pathway targeting with microglial <scp>EVs</scp>
EVs<sup>M1</sup> induced neuroinflammation via the CCR5-GPCRs-Ras-MAPK pathway, with EVs<sup>M1-CCR5</sup> showing protective effects on POCD progression, suggesting a new therapeutic strategy for POCD management via targeted modification of microglial EVs.
Authors
- Qinghe Xing (ORCID: https://orcid.org/0000-0003-1780-4761)
- Jian‐jun Yang
- Qi Zheng (ORCID: https://orcid.org/0000-0002-1196-4193)
- Yingying Zhao (ORCID: https://orcid.org/0000-0001-5902-1306)
- Haitao Wang (ORCID: https://orcid.org/0000-0003-0338-4364)
- Yu Su (ORCID: https://orcid.org/0009-0004-5001-9225)
- Bin Cao (ORCID: https://orcid.org/0000-0001-8743-2743)
- Lan Ding
- Junlin Peng
- Li Wang (ORCID: https://orcid.org/0000-0003-2068-7535)
Institutions
- Fudan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1111/cns.14924
- Citations
- 19
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.70
Funders
- National Natural Science Foundation of China