Lactobacillus-Polydopamine System for Targeted Drug Delivery in Overactive Bladder: Evidence from Bladder Cell Spheroids, Rat Models, and Urinary Microbiome Profiling
The results highlight LPS as a promising drug carrier for targeted OAB therapy via penetration into bladder tissues. This bacteriotherapy approach may overcome limitations of current systemic OAB medications. Lactobacillus, a probiotic bacterium present in the urinary tract microbiome, was hypothesized to adhere to and penetrate the bladder wall when coated with PDA nanoparticles, making it a suitable candidate for localized drug delivery.
Authors
- Zuhaer Yisha
- Tongzu Liu (ORCID: https://orcid.org/0000-0002-9613-8949)
- Guanyi Wang (ORCID: https://orcid.org/0000-0003-3424-4153)
- Hongyu Lan
- Guiyong Liu (ORCID: https://orcid.org/0000-0002-5327-0720)
- Xiaolong Wang (ORCID: https://orcid.org/0000-0001-6142-9722)
- Qingfeng Yu (ORCID: https://orcid.org/0000-0001-7316-627X)
- Zijian Wang (ORCID: https://orcid.org/0009-0008-0388-1129)
- Aodun Gu
- Peibin Cen
- Linfa Guo
Institutions
- Wuhan University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Qianjiang Central Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/ijn.s465745
- Citations
- 1
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Natural Science Foundation of China