Isoflurane conditioning improves functional outcomes after peripheral nerve injury in a sciatic cut repair murine model
Isoflurane conditioning (3- and 6-day groups) resulted in improvement in functional outcomes at 12 weeks post peripheral nerve injury and repair in a murine model. Future experiments should be focused on identifying the therapeutic window of isoflurane conditioning and exploring the underlying molecular mechanisms responsible for isoflurane conditioning induced neuroprotection in PNI.
Authors
- Gregory J. Zipfel (ORCID: https://orcid.org/0000-0003-2737-9084)
- Umeshkumar Athiraman (ORCID: https://orcid.org/0000-0002-9086-0607)
- Matthew R. MacEwan (ORCID: https://orcid.org/0000-0002-7911-3408)
- Wilson Z. Ray (ORCID: https://orcid.org/0000-0002-3006-8562)
- Yan Yan (ORCID: https://orcid.org/0000-0002-5917-1475)
- Yameng Xu
Institutions
- Washington University in St. Louis (US)
- Hope Center for Neurological Disorders (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/fneur.2024.1406463
- Citations
- 2
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.82