Comprehensive genomic and spatial immune infiltration analysis of survival outliers in extensive-stage small cell lung cancer receiving first-line chemoimmunotherapy
For ES-SCLC patients receiving first-line chemoimmunotherapy, alterations in DLL3, KMT2B, HGF, EPHA3, and ADGRB3 and a greater proportion of M1-like macrophages infiltration in all locations were predictors of favorable survival, while MCL1 and STMN1 amplification, as well as a greater proportion of CD8<sup>+</sup> T cells infiltrating the tumor stroma, predicted worse survival.
Authors
- Xiaoying Wu (ORCID: https://orcid.org/0000-0002-2977-3280)
- Qinpei Cheng
- Fufeng Wang (ORCID: https://orcid.org/0000-0002-8933-4909)
- Jingyuan Xie (ORCID: https://orcid.org/0000-0002-5508-0664)
- Zijing Cai
- Tangfeng Lv (ORCID: https://orcid.org/0000-0001-7224-8468)
- Yuxin Jiang (ORCID: https://orcid.org/0009-0004-7329-5708)
- Ke Xu (ORCID: https://orcid.org/0000-0002-7241-0100)
- Ping Zhan
- Wanjun Lu
- Yong Song
Institutions
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1016/j.intimp.2024.112901
- Citations
- 8
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.26