Lingguizhugan oral solution alleviates MASLD by regulating bile acids metabolism and the gut microbiota through activating FXR/TGR5 signaling pathways
Altogether, the findings of this study suggest that modulating microbiota-BA-FXR/TGR5 signaling pathway may be a potential mechanism of action of LGZG oral solution for the treatment of MASLD.
Authors
- Mo Liu (ORCID: https://orcid.org/0000-0002-7576-9151)
- Huimin Cao (ORCID: https://orcid.org/0000-0002-4913-6342)
- Ruibo Guo
- Zixu Zhang (ORCID: https://orcid.org/0009-0002-8312-377X)
- Lu Zhang (ORCID: https://orcid.org/0000-0003-3494-6913)
- Xuetao Li (ORCID: https://orcid.org/0000-0002-0608-4669)
- Yang Liu (ORCID: https://orcid.org/0000-0003-0487-0006)
- Jiahua Wang (ORCID: https://orcid.org/0000-0002-5299-6968)
- Liang Kong (ORCID: https://orcid.org/0000-0002-5721-0290)
- Yu Yang (ORCID: https://orcid.org/0000-0001-9036-8885)
- Juan Zang
Institutions
- Liaoning University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/fphar.2024.1426049
- Citations
- 16
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.19