Mechanism of action of quercetin in regulating cellular autophagy in multiple organs of Goto-Kakizaki rats through the PI3K/Akt/mTOR pathway
Quercetin markedly ameliorates liver, spleen, and kidney damage in GK rats, potentially through the inhibition of the PI3K/Akt/mTOR pathway, promoting autophagy. This research offers a rationale to the therapeutic potential of quercetin in mitigating organ damage associated with diabetes.
Authors
- Zhiqun Guo (ORCID: https://orcid.org/0000-0003-0230-2179)
- Lemei Zhu (ORCID: https://orcid.org/0000-0003-0477-3759)
- M. Li
- Mingxu Qi (ORCID: https://orcid.org/0000-0001-9934-7618)
- Xuemin Zou
- Yuan Zhang (ORCID: https://orcid.org/0000-0002-8842-2691)
- Jingyu Zhang (ORCID: https://orcid.org/0000-0003-4451-0072)
- Jiaqi Qing
- Xi Li
- Zengwei Xing
Institutions
- Changsha Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/fmed.2024.1442071
- Citations
- 9
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 3.48