Unlocking the puzzle: non-defining mutations in SARS-CoV-2 proteome may affect vaccine effectiveness
Vaccine coverage associations appear to be influenced by the mutations harbored by marketed vaccines. An analysis of the physicochemical properties of amino acid revealed that primarily hydrophobic and polar amino acid substitutions occurred. Our results suggest that non-defining mutations across the proteome of SARS-CoV-2 variants could affect the extent of protection of the COVID-19 vaccine. In addition, alteration of the physicochemical characteristics of viral amino acids could potentially disrupt protein structure or function or both.
Authors
- Carlos Óscar S. Sorzano (ORCID: https://orcid.org/0000-0002-9473-283X)
- Nuria Eugenia Campillo (ORCID: https://orcid.org/0000-0002-9948-2665)
- Eugenia Ulzurrun (ORCID: https://orcid.org/0009-0008-7665-2167)
- Ana Grande-Pérez (ORCID: https://orcid.org/0000-0002-2821-062X)
- Daniel del Hoyo (ORCID: https://orcid.org/0009-0005-3321-1810)
- César Guevara (ORCID: https://orcid.org/0000-0003-1571-5829)
- Carmen Gil (ORCID: https://orcid.org/0000-0002-3882-6081)
Institutions
- Consejo Superior de Investigaciones Científicas (ES)
- Centro Nacional de Biotecnología (ES)
- Universidad Indoamérica (EC)
- Institute of Mathematical Sciences (ES)
- Universidad de Málaga (ES)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/fpubh.2024.1386596
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00