Targeting transcription factor pu.1 for improving neurologic outcomes after spinal cord injury
Our study reveals a significant correlation between lipid metabolism disturbance post-SCI and transcription factor pu.1 upregulation, specifically in macrophages/microglia at the lesion site. Thus, targeted pu.1 modulation has the potential to yield promising results by substantially diminishing the deposition of lipid metabolism byproducts at the lesion site and fostering a milieu conducive to SCI repair.
Authors
- Yihui Bi (ORCID: https://orcid.org/0000-0001-5935-2295)
- Fangru Ouyang
- Jian Jian Li (ORCID: https://orcid.org/0000-0003-3694-9675)
- Yang Luo (ORCID: https://orcid.org/0000-0002-8709-0103)
- Yi Shi
- Yuanzhe Zhao (ORCID: https://orcid.org/0000-0003-1066-9253)
- Jingwen Wang (ORCID: https://orcid.org/0000-0002-9461-2301)
- Li Cheng (ORCID: https://orcid.org/0000-0001-7928-4170)
- Juehua Jing (ORCID: https://orcid.org/0000-0001-5599-5672)
- Congpeng Meng
- Meige Zheng
- Zhida Ma
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/fnins.2024.1418615
- Citations
- 2
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- National Natural Science Foundation of China
- Anhui Medical University
- Natural Science Foundation of Anhui Province