Biotransformation of Glaucic Acid Isolated from the Root of <i>Lindera glauca</i> by the Endophytic Fungi <i>Penicillium Chrysogenum</i> SHJ‐07
Glaucic acid isolated from the root of Lindera glauca, was investigated by the biotransformation methods via the endophytic fungi, resulting in the production of five new glausesquiterpenes A-E (1-5), along with a known analogue 6. Their structures were elucidated based on spectroscopic methods and electronic circular dichroism (ECD) calculations. In the bioassays, glausesquiterpene A (1) showed good inhibitory activity of NO production in LPS-activated RAW 264.7 macrophages with an IC<sub>50</sub> value of 20.1 μM than positive control (Indomethacin, IC<sub>50</sub> 24.1 μM). Further in vitro studies demonstrated that glausesquiterpene A significantly suppressed the protein expression of iNOS and COX-2 at the concentration of 25.0 μM.
Authors
- Hui Cui (ORCID: https://orcid.org/0000-0003-4281-016X)
- Zelin Chen
- Yongling Long (ORCID: https://orcid.org/0000-0003-2533-7614)
- Qinghui Zou
- Anni Luo
- Jinqin Wei
- Jingxin He
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Guangdong Pharmaceutical University (CN)
- Guangzhou University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1002/cbdv.202401658
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China