Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin‐2 dephosphorylation and impairing mitochondrial quality control
Pgam5 knockout attenuates alcohol-induced cardiac histopathology and heart dysfunction in male mice. Pgam5 KO reduces alcohol-induced myocardial inflammation, lipid peroxidation and metabolic dysfunction in male mice. Pgam5 depletion protects mitochondrial function in alcohol-exposed male mouse cardiomyocytes. Pgam5 depletion normalises MQC in ACM. EtOH impairs MQC through inducing Phb2 dephosphorylation at Ser91. Pgam5 interacts with Phb2 and induces Phb2 dephosphorylation. Transgenic mice expressing a Ser91 phospho-mimetic Phb2 mutant are resistant to ACM.
Authors
- Jun Tao (ORCID: https://orcid.org/0000-0003-2899-0248)
- Ruibing Li (ORCID: https://orcid.org/0000-0002-1311-1012)
- Xing Chang (ORCID: https://orcid.org/0000-0002-3788-9881)
- Qingyong He (ORCID: https://orcid.org/0000-0002-5885-8005)
- Junmeng Zheng (ORCID: https://orcid.org/0000-0002-4243-8209)
- Junxiong Qiu (ORCID: https://orcid.org/0000-0002-9768-0545)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Hubei University of Science and Technology (CN)
- Guang’anmen Hospital (CN)
- Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/ctm2.1806
- Citations
- 14
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.27