Factors associated with elevated SARS-CoV-2 immune response in children and adolescents
Older age, duration since the last immunity challenge (vaccine or infection), and vaccination status were associated with heightened spike antibody responses, highlighting the nuanced immune dynamics in the pediatric population. A significant proportion of children/adolescents continue to have asymptomatic infection, which has important public health implications.
Authors
- Sarah Elizabeth Messiah (ORCID: https://orcid.org/0000-0001-6685-2175)
- Melissa A. Valerio-Shewmaker (ORCID: https://orcid.org/0000-0001-6563-0714)
- Emma Bergqvist
- Jennifer A. Shuford
- Ashraf Yaseen (ORCID: https://orcid.org/0000-0002-0598-3419)
- Leqing Wu
- Eric Boerwinkle (ORCID: https://orcid.org/0000-0001-8813-0544)
- Rhiana A. Abbas
- Jessica A. Ross (ORCID: https://orcid.org/0000-0001-6579-0785)
- Mark A. Silberman
- Stephen J. Pont (ORCID: https://orcid.org/0000-0003-0200-0453)
- Haoting Han (ORCID: https://orcid.org/0000-0002-4539-5574)
- H. Gandhi (ORCID: https://orcid.org/0000-0002-1156-515X)
- Harold W. Kohl (ORCID: https://orcid.org/0000-0001-5426-2733)
- David Lakey (ORCID: https://orcid.org/0000-0003-1780-6396)
- Stacia M. DeSantis (ORCID: https://orcid.org/0000-0002-3400-1031)
- Yashar Talebi (ORCID: https://orcid.org/0000-0002-1493-8986)
- Michael D. Swartz (ORCID: https://orcid.org/0000-0003-3953-8775)
- Lindsay N. Padilla (ORCID: https://orcid.org/0000-0003-4295-4171)
- Rachit Sabharwal
- Ximena Flandes Amavisca
- Michael O. Gonzalez (ORCID: https://orcid.org/0000-0002-8565-4809)
Institutions
- Texas Department of State Health Services (US)
- The University of Texas System (US)
- The University of Texas at Tyler (US)
- Experimental Pathology Laboratories (US)
- The University of Texas at Austin (US)
- The University of Texas Health Science Center at Tyler (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/fped.2024.1393321
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- U.S. Department of State
- University of Texas System
- University of Texas Health Science Center at Houston
- Texas Department of State Health Services