Effect of glycerol on properties of chitosan/chlorhexidine membranes and antibacterial activity against Streptococcus mutans
Mechanical results indicated that chitosan membranes' rugosity, strength, flexion, and thickness differed at loading 1, 3, 5, 10, 15, and 20% of glycerol (<i>p</i> < 0.05). The chitosan membranes' rugosity, dissolution, strength, and pH results were significantly enhanced by the presence of glycerol at 3, 5, and 10% concentrations. In this investigation, the antimicrobial activity model used was the inhibition of <i>Streptococcus mutans</i> CDBB-B-1455 by chitosan-chlorhexidine membranes. It was observed that there was no change in inhibition with different concentrations of glycerol. The results suggest that chitosan-glycerol-chlorhexidine membranes may be a potential candidate for topical antiseptic application in buccal-dental disorders caused by <i>S. mutans</i>, such as caries, periodontal diseases, and oral squamous cell carcinoma, helping to prevent the development of serious conditions that can compromise human health.
Authors
- Abigailt Flores‐Ledesma (ORCID: https://orcid.org/0000-0002-8136-4820)
- Eric Reyes‐Cervantes (ORCID: https://orcid.org/0000-0001-6436-0900)
- América Paulina Rivera-Urbalejo (ORCID: https://orcid.org/0000-0002-6452-6808)
- Jesús Hernández‐Juárez (ORCID: https://orcid.org/0000-0002-5505-1097)
- Miguel Ángel Casillas Santana (ORCID: https://orcid.org/0000-0003-0288-9117)
- Brenda Castillo (ORCID: https://orcid.org/0000-0003-0142-895X)
- Laura Abisaí Pazos-Rojas (ORCID: https://orcid.org/0000-0002-0945-4012)
- Manuel E. Medina (ORCID: https://orcid.org/0000-0002-6285-2570)
- José Alberto Hachity-Ortega
- Beatriz Xochitl Ávila-Curiel
- Paola G Gordillo-Guerra
- Alberto V Jerezano-Domínguez
- Diana del C. Pazos-Guarneros
- Karla Aimée Parra-Solar
- Ismael Juárez-Díaz
- Mayra González-Martínez
Institutions
- Universidad Veracruzana (MX)
- Instituto Tecnológico de Oaxaca (MX)
- Universidad Autónoma Metropolitana (MX)
- Benemérita Universidad Autónoma de Puebla (MX)
- Tecnológico de Monterrey (MX)
- Benito Juárez Autonomous University of Oaxaca (MX)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/fmicb.2024.1430954
- Citations
- 7
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- Instituto Tecnológico y de Estudios Superiores de Monterrey
- Vicerrectoría de Investigación y Estudios de Posgrado, Benemérita Universidad Autónoma de Puebla