Time of day differences in the regulation of glutathione levels in the rat lens
The lens contains the key components of a circadian clock, and time-of-day differences exist in the expression of GSH and GSH related enzymes involved in maintaining GSH homeostasis. GSH levels in the rat lens were highest at the start of night which represents the active phase of the rat when high GSH levels may be required to counteract oxidative stress induced by cellular metabolism. Future work to directly link the clock to regulation of GSH levels in the lens will be important in determining whether the clock can be used to help restore GSH levels in the lens.
Authors
- Paul J. Donaldson (ORCID: https://orcid.org/0000-0002-4008-1138)
- Renita M. Martis (ORCID: https://orcid.org/0000-0002-8143-2563)
- Zhou-ai Wang
- Haruna Suzuki‐Kerr (ORCID: https://orcid.org/0000-0002-4860-3527)
- Raewyn C. Poulsen (ORCID: https://orcid.org/0000-0002-3788-6410)
- Tai X. Nguyen
- Julie C. Lim (ORCID: https://orcid.org/0000-0002-6307-7297)
- Christopher J. J. Lim
- Bo Li (ORCID: https://orcid.org/0000-0002-0439-5666)
Institutions
- University of Auckland (NZ)
Publication Details
- Journal
- Frontiers in Ophthalmology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/fopht.2024.1407582
- Citations
- 1
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.27
Funders
- Royal Society Te Apārangi
- Marsden Fund