Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes
CNOT3 plays a protective role in ALI by suppressing expression of pro-inflammatory genes <i>Il1b</i> and <i>Nos2</i> through both post-transcriptional and transcriptional mechanisms, including mRNA stability control of Spi1.
Authors
- Yousef Mohamad Khalil
- Tomokazu Yamaguchi (ORCID: https://orcid.org/0000-0002-8362-0031)
- Keiji Kuba (ORCID: https://orcid.org/0000-0002-2203-5293)
- Midori Hoshizaki
- Ryo Ozawa
- Ken Yamaura
- Kazuma Okawara
- Yutaro Kammura
- Fukuda Masayuki
- Takafumi Minato (ORCID: https://orcid.org/0009-0007-6659-5253)
- Yumiko Imai (ORCID: https://orcid.org/0000-0003-4615-4833)
- Masafumi Nakamura
Institutions
- Kyushu University (JP)
- Akita University (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/jir.s468612
- Citations
- 2
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Japan Science and Technology Agency