Sex-specific alterations in the gut and lung microbiome of allergen-induced mice
Overall, our findings indicate that intranasal allergen challenge triggers sex-specific changes in both gut and lung microbiomes, and induces sex-specific lung inflammation, AHR, and lung inflammatory gene expression pathways, suggesting a contribution of the lung-gut axis in allergic airway disease.
Authors
- Dustin Rousselle (ORCID: https://orcid.org/0000-0003-3377-9324)
- Maksat Babayev
- Shikha Sharma (ORCID: https://orcid.org/0000-0001-5948-292X)
- Douglas B. Rusch (ORCID: https://orcid.org/0000-0002-1066-2687)
- Patricia Silveyra (ORCID: https://orcid.org/0000-0001-7083-8915)
- Christopher M. Hemmerich
- Rachel Alford
- Carolyn Damilola Ekpruke (ORCID: https://orcid.org/0000-0002-9045-4457)
- Kyle Davis (ORCID: https://orcid.org/0000-0003-1874-9741)
- Erik Parker
Institutions
- Indiana University Bloomington (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Frontiers in Allergy
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3389/falgy.2024.1451846
- Citations
- 7
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.29