Microvascular angiotensin II type 2 receptor function is enhanced in young females and declines in a model of murine aging
These data demonstrate enhanced microvascular AT2R function in young female mice and young women. There is a female-specific loss of AT2R function with age in mice, concomitant with declining AT2R expression. These findings implicate AT2R as a sex-specific target for microvascular dysfunction and aging-associated cardiovascular disease.
Authors
- Casey G. Turner (ORCID: https://orcid.org/0000-0001-8677-5912)
- Lakshmi Pulakat (ORCID: https://orcid.org/0000-0002-1430-2945)
- Iris Z. Jaffe (ORCID: https://orcid.org/0000-0001-9300-1253)
- Jennifer J. DuPont (ORCID: https://orcid.org/0000-0002-7831-8786)
- Ayan R. Patel (ORCID: https://orcid.org/0000-0003-1984-1400)
- Qing Lu (ORCID: https://orcid.org/0000-0003-2380-5330)
- Karla de Oliveira
Institutions
- Tufts Medical Center (US)
Publication Details
- Journal
- The Journal of Cardiovascular Aging
- Published
- 2024-08-15
- DOI
- https://doi.org/10.20517/jca.2024.09
- Citations
- 3
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- American Heart Association
- National Institutes of Health