Ocrelizumab in MS patients with persistence of disease activity after alemtuzumab: A multi-center Italian study

OCR after two ALM courses seemed to be safe and effective. Early IgM hypogammaglobulinemia occurred in a high proportion of patients. The evidence of inflammatory activity between ALM courses seemed to increase the risk of MS re-activation on OCR treatment.

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Publication Details

Journal
Multiple Sclerosis Journal
Published
2024-08-01
DOI
https://doi.org/10.1177/13524585241266509
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Ocrelizumab in MS patients with persistence of disease activity after alemtuzumab: A multi-center Italian study

Giancarlo Coghe, Mauro Zaffaroni, Carolina Gabri Nicoletti, Lucia Moiola et al.
Multiple Sclerosis Journal
Multiple Sclerosis Research Studies
article

Ocrelizumab in MS patients with persistence of disease activity after alemtuzumab: A multi-center Italian study

Giancarlo Coghe, Mauro Zaffaroni, Carolina Gabri Nicoletti, Lucia Moiola, Girolama Alessandra Marfia, Federica Pinardi, Maria Cellerino, Jessica Frau, Massimiliano Mirabella, Marco Vercellino, Valentina Torri Clerici, Marco Ronzoni, Agostino Nozzolillo, E Deloya Tomas, Antonio Uccelli, Paola Grossi, Maria Petracca, Roberta Lanzillo, Matilde Inglese, Paola Cavalla, Giovanni Novi, Caterina Lapucci, Assunta Bianco, Eleonora E. Cocco, Vincenzo Brescia Morra, Maria Teresa Ferrò, Doriana Landi
article en

Abstract

OCR after two ALM courses seemed to be safe and effective. Early IgM hypogammaglobulinemia occurred in a high proportion of patients. The evidence of inflammatory activity between ALM courses seemed to increase the risk of MS re-activation on OCR treatment.

Multiple Sclerosis JournalVol. 30(9)
Università Cattolica del Sacro Cuore (IT), University of Rome Tor Vergata (IT), Vita-Salute San Raffaele University (IT), University of Cagliari (IT), Agostino Gemelli University Polyclinic (IT), Regione Puglia (IT), Istituto delle Scienze Neurologiche di Bologna (IT), Ospedale Policlinico San Martino (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Fondazione IRCCS Istituto Neurologico Carlo Besta (IT), Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT), Azienda Socio Sanitaria Territoriale della Valle Olona, Aziende Socio Sanitaria Territoriale Rhodense, University of Naples Federico II (IT), University of Genoa (IT), Sapienza University of Rome (IT)
Fondazione Italiana Sclerosi Multipla, Ministero della Salute
Good health and well-being
Openalex Percentile: Top 79%
Multiple Sclerosis Research Studies
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