Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing

Fluid shear stress (FSS) from blood flow, sensed by the vascular endothelial cells (ECs) that line all blood vessels, regulates vascular development during embryogenesis, controls adult vascular physiology and determines the location of atherosclerotic plaque formation. Although a number of papers have reported a crucial role for cell-cell adhesions or adhesion receptors in these processes, a recent publication has challenged this paradigm, presenting evidence that ECs can very rapidly align in fluid flow as single cells without cell-cell contacts. To address this controversy, four independent laboratories assessed EC alignment in fluid flow across a range of EC cell types. These studies demonstrate a strict requirement for cell-cell contact in shear stress sensing over timescales consistent with previous literature and inconsistent with the newly published data.

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Publication Details

Journal
Journal of Cell Science
Published
2024-08-15
DOI
https://doi.org/10.1242/jcs.262348
Citations
4
Primary Topic
Erythrocyte Function and Pathophysiology
Type
article
Field-Weighted Citation Impact
1.31

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article

Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing

Blanca Tardajos Ayllón, Vedanta Mehta, Ellie Tzima, Jovana Serbanovic‐Canic et al.
4 citations
Journal of Cell Science
Erythrocyte Function and Pathophysiology
1.31
article

Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing

Blanca Tardajos Ayllón, Vedanta Mehta, Ellie Tzima, Jovana Serbanovic‐Canic, Bernadette A. Miao, Jiayu Zhu, Yun Fang, Martin Alexander Schwartz, X Shaka, Paul C. Evans, Claire Aitken
article en
4 citations

Abstract

Fluid shear stress (FSS) from blood flow, sensed by the vascular endothelial cells (ECs) that line all blood vessels, regulates vascular development during embryogenesis, controls adult vascular physiology and determines the location of atherosclerotic plaque formation. Although a number of papers have reported a crucial role for cell-cell adhesions or adhesion receptors in these processes, a recent publication has challenged this paradigm, presenting evidence that ECs can very rapidly align in fluid flow as single cells without cell-cell contacts. To address this controversy, four independent laboratories assessed EC alignment in fluid flow across a range of EC cell types. These studies demonstrate a strict requirement for cell-cell contact in shear stress sensing over timescales consistent with previous literature and inconsistent with the newly published data.

Journal of Cell ScienceVol. 137(17)
Queen Mary University of London (GB), Yale University (US), University of Oxford (GB), University of Chicago (US), William Harvey Research Institute (GB), University of Sheffield (GB)
American Heart Association, Yale University, British Heart Foundation, U.S. Public Health Service, Medical Research Council
Good health and well-being
Openalex Percentile: Top 19%
Erythrocyte Function and Pathophysiology
1.31
DOIOpen Access PDFOpenAlex
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