Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence
BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.
Authors
- Diana Jurk (ORCID: https://orcid.org/0000-0003-4486-0857)
- Susana Rosa (ORCID: https://orcid.org/0000-0003-4477-2574)
- Inês Tomé (ORCID: https://orcid.org/0000-0001-8147-1004)
- Irina S. Moreira (ORCID: https://orcid.org/0000-0003-2970-5250)
- Lino Ferreira (ORCID: https://orcid.org/0000-0001-8985-9302)
- Thomas von Zglinicki (ORCID: https://orcid.org/0000-0002-5939-0248)
- Andreia Vilaça (ORCID: https://orcid.org/0000-0002-7063-280X)
- João P. Novo (ORCID: https://orcid.org/0000-0001-8015-2685)
- Lucy Gee
- Carolina A. Caetano
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Florida (US)
- University of Coimbra (PT)
- Newcastle University (GB)
Publication Details
- Journal
- Aging Cell
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1111/acel.14270
- Citations
- 14
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.46
Funders
- Directorate for Biological Sciences
- HORIZON EUROPE Framework Programme
- Biotechnology and Biological Sciences Research Council
- Fundação para a Ciência e a Tecnologia
- National Institute on Aging
- HORIZON EUROPE European Innovation Council