Zoledronate alleviates subchondral bone collapse and articular cartilage degeneration in a rat model of rotator cuff tear arthropathy
The humeral head subchondral bone was decreased in patients with CTA. In the mCTA model, the collapse and osteoarthritic changes were prevented by zoledronate administration. Zoledronate seemed to suppress the number of M1 macrophages in the synovium and osteoclasts in the subchondral bone.
Authors
- Takayuki Ide (ORCID: https://orcid.org/0009-0002-3094-1445)
- Hiroki Tawaratsumida (ORCID: https://orcid.org/0009-0003-8293-3567)
- Tomohiro Iuchi (ORCID: https://orcid.org/0009-0002-7523-2845)
- Takasuke Miyazaki (ORCID: https://orcid.org/0000-0003-0449-8478)
- Shingo Maesako (ORCID: https://orcid.org/0000-0003-2145-4768)
- Toshiro Ijuin (ORCID: https://orcid.org/0009-0001-3714-8944)
- Shingo Maeda (ORCID: https://orcid.org/0000-0002-2737-3902)
- Noboru Taniguchi (ORCID: https://orcid.org/0000-0002-1391-144X)
- Yusuke Masuda (ORCID: https://orcid.org/0009-0004-8942-1350)
Institutions
- Kagoshima University (JP)
Publication Details
- Journal
- Osteoarthritis and Cartilage
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1016/j.joca.2024.08.005
- Citations
- 3
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Japan Society for the Promotion of Science