Microparticle Mediated Delivery of Apelin Improves Heart Function in Post Myocardial Infarction Mice
Poly(lactic-co-glycolic acid) microparticles prolonged the apelin release time in the mouse hearts. Epicardial delivery of the apelin-containing microparticle-embedded patch protects mice from both acute and chronic MI-induced cardiac dysfunction, inhibits cardiac fibrosis, and improves left ventricular remodeling.
Authors
- Verah Nyarige (ORCID: https://orcid.org/0000-0001-6707-3384)
- Alexander Yu (ORCID: https://orcid.org/0000-0002-7246-2269)
- Michael Rubart (ORCID: https://orcid.org/0000-0002-7386-6943)
- Huiliang Qiu
- Ling Tang (ORCID: https://orcid.org/0000-0002-5378-9442)
- Jingwei Xie (ORCID: https://orcid.org/0000-0002-8126-1397)
- Wuqiang Zhu (ORCID: https://orcid.org/0000-0001-5217-7789)
- Bing Xu (ORCID: https://orcid.org/0000-0002-2903-578X)
- H Adám (ORCID: https://orcid.org/0000-0003-4792-9338)
- Michelle Jang
- Aaron Yang (ORCID: https://orcid.org/0000-0002-6041-3654)
- Jun Liao (ORCID: https://orcid.org/0000-0003-1049-5783)
- Yajuan Su (ORCID: https://orcid.org/0000-0003-2418-824X)
- Pengsheng Li (ORCID: https://orcid.org/0000-0001-8867-1527)
- Brady Killham
- Houjia Chen
Institutions
- Mayo Clinic in Arizona (US)
- Bioengineering Center (RU)
- Indiana University – Purdue University Indianapolis (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1161/circresaha.124.324608
- Citations
- 16
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 7.17
Funders
- American Heart Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- Congressionally Directed Medical Research Programs