Role of surgery in the treatment of pediatric low-grade glioma with various degrees of brain stem involvement
The first surgical intervention in BS-pLGG can control disease alone in overall 50% of cases, with rates differing greatly according to location (Groups 1 > 2 > 3 > 4), with acceptable low morbidity. The second look surgery is warranted except in medullary tumors. With multimodality treatments almost 90% of patients can obtain remission or stable disease after > 5 years of follow-up. An integrated multimodal and multidisciplinary approach aiming at minimal safe residual disease, combining surgery, chemo-, targeted therapy, and, as an exception, radiation therapy, is mandatory.
Authors
- Martin U. Schuhmann (ORCID: https://orcid.org/0000-0001-9843-7486)
- Martin Ebinger (ORCID: https://orcid.org/0000-0002-4229-8058)
- Julian Zipfel (ORCID: https://orcid.org/0000-0003-4725-713X)
- Jens Schittenhelm (ORCID: https://orcid.org/0000-0002-9168-6209)
- Marcos Soares Tatagiba (ORCID: https://orcid.org/0000-0002-1627-9937)
- Jonas Tellermann
- Katalin Lőrincz
- David Gorodezki (ORCID: https://orcid.org/0000-0002-7311-5840)
Institutions
- University Children's Hospital Tübingen (DE)
- Hertie Institute for Clinical Brain Research (DE)
- STZ eyetrial (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Child s Nervous System
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1007/s00381-024-06561-y
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- Universitätsklinikum Tübingen