Converging deep learning and human-observed tumor-adipocyte interaction as a biomarker in colorectal cancer
By proving the substantial overlap between human-observed SARIFA and DL-based TAF as morphologic biomarkers, we demonstrate that linking DL-based image features to independently developed histopathologic biomarkers is a promising tool in the identification of clinically and biologically meaningful biomarkers. Adipocyte-tumor-cell interactions seem to be crucial in CRC, which should be considered as biomarkers for further investigations.
Authors
- David F. Steiner (ORCID: https://orcid.org/0000-0003-1297-0023)
- Hannah S. Muti
- Bruno Märkl (ORCID: https://orcid.org/0000-0002-7704-850X)
- Vincenzo L’Imperio (ORCID: https://orcid.org/0000-0002-9284-2998)
- Kurt Zatloukal (ORCID: https://orcid.org/0000-0001-5299-7218)
- Nic G. Reitsam (ORCID: https://orcid.org/0000-0002-0070-3158)
- Markus Plass (ORCID: https://orcid.org/0000-0003-2718-7648)
- Bianca Grosser (ORCID: https://orcid.org/0000-0003-4957-4876)
- Jakob Nikolas Kather (ORCID: https://orcid.org/0000-0002-3730-5348)
- Ellery Wulczyn
- Veselin Grozdanov (ORCID: https://orcid.org/0000-0002-0825-7383)
- Heimo Müller (ORCID: https://orcid.org/0000-0002-9691-4872)
Institutions
- Google (United States) (US)
- University of Leeds (GB)
- University of Augsburg (DE)
- Universität Ulm (DE)
- Medical University of Graz (AT)
- Heidelberg University (DE)
- Cancer Research UK (GB)
- University Hospital Heidelberg (DE)
- Fresenius (Germany) (DE)
- National Center for Tumor Diseases (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University Hospital Carl Gustav Carus (DE)
- University of Milano-Bicocca (IT)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1038/s43856-024-00589-6
- Citations
- 12
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.42
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- European Commission
- Deutscher Akademischer Austauschdienst
- Bundesministerium für Bildung und Forschung
- Bundesministerium für Gesundheit
- Deutsche Krebshilfe
- Gemeinsame Bundesausschuss
- HORIZON EUROPE Framework Programme
- Leeds Biomedical Research Centre