Effects of strategic white matter hyperintensities of cholinergic pathways on basal forebrain volume in patients with amyloid-negative neurocognitive disorders
We identified a significant correlation between strategic WMH burden in the cholinergic pathway and BF atrophy independently of amyloid positivity and WMH severity. These results suggest a mechanism of cholinergic neuronal loss through the dying-back phenomenon and provide a rationale that strategic WMH assessment may help identify target groups that may benefit from acetylcholinesterase inhibitor treatment.
Authors
- Jee Hoon Roh (ORCID: https://orcid.org/0000-0002-3243-0529)
- Jae‐Sung Lim (ORCID: https://orcid.org/0000-0001-6157-2908)
- Chong Hyun Suh (ORCID: https://orcid.org/0000-0002-4737-0530)
- E‐Nae Cheong (ORCID: https://orcid.org/0000-0003-1270-5385)
- Hwon Heo (ORCID: https://orcid.org/0000-0002-6103-4680)
- Yoojin Lee (ORCID: https://orcid.org/0000-0003-2475-5857)
- Jae‐Hong Lee (ORCID: https://orcid.org/0000-0001-7368-4560)
- Ye Eun Kim (ORCID: https://orcid.org/0000-0003-3190-0776)
- Jae Woo Kim (ORCID: https://orcid.org/0000-0003-3054-6306)
Institutions
- Ulsan College (KR)
- Korea University (KR)
- Korea University Medical Center (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1186/s13195-024-01536-2
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65