Formulation and Evaluation of Transdermal Patches of Metformin Hydrochloride using HPMC K100 as Release Retarding Agent

The present study was designed to develop a suitable matrix type transdermal drug delivery systems of Metformin HCL using two different polymeric combinations, E RS100 and HPMC E 15; E RL 100 with HPMC E 15. E RL100 and E RS 100 are acrylic acid matrices which have been used to make drug-polymer matrix films for transdermal delivery systems which are reported as compatible with many drugs. Penetration enhancers that alter the partitioning can be useful to enhance the drug permeation (6). In this study various penetration enhancers D-Limonene (4), Oleic acid (5) and were used in different concentrations to determine their effect on permeation of drug.