AB063. NF2 expression is linked to meningioma location and visual symptoms in Indonesian patients

Background: Meningioma is the most common type of primary central nervous system tumor. The development of meningioma is often influenced by the neurofibromin-2 (NF2) gene. Studies have demonstrated that the genetic profile of meningioma is linked to their location. However, it is currently unclear whether there is an association between NF2 expression and meningioma location in the Indonesian population. Methods: This retrospective cross-sectional analysis included 153 histologically confirmed meningioma patients admitted to Dr. Sardjito General Hospital in Yogyakarta, Indonesia. The study utilized immunohistochemistry (IHC) staining to determine the NF2/Merlin expression. Meningioma locations were established using brain magnetic resonance imaging (MRI) or computerized tomography (CT) scans before surgery. The data on other variables were collected from medical records. Results: Of all the patients, 118 (77.1%) tested positive for NF2/Merlin expression. The subjects in the study comprised 126 (82.4%) World Health Organization (WHO) grade I tumors and 27 (17.6%) WHO grade II and III tumors. The research showed that 85 (55.6%) of the tumors were located in the spheno-orbital region. The study found a significant association between NF2 positive expression and meningioma location in the spheno-orbital region [odds ratio (OR) 2.51, P=0.02]. Therefore, the patients who tested positive for NF2 had higher chances of visual impairment (P=0.04). Conclusions: This study showed positive NF2 expression is associated with meningioma location in spheno-orbital and patients’ visual symptoms.