Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding
Our research indicates that TTN effectively treats ALI and autoimmune illnesses mediated by the cGAS-STING pathway by inhibiting the abnormal activation of this pathway.
Authors
- Qing Yao (ORCID: https://orcid.org/0000-0003-0115-9075)
- Xiaohe Xiao (ORCID: https://orcid.org/0000-0002-2836-2738)
- Zhaofang Bai (ORCID: https://orcid.org/0000-0002-6208-150X)
- Jincai Wen
- Chengwei Li (ORCID: https://orcid.org/0000-0002-7462-6415)
- Simin Chen (ORCID: https://orcid.org/0000-0003-0413-9571)
- Yinghao Wang (ORCID: https://orcid.org/0000-0002-1928-0538)
- Xinru Wen
- Xiaoyan Zhan (ORCID: https://orcid.org/0000-0002-2446-5967)
- Xiu Ye (ORCID: https://orcid.org/0000-0002-5878-9257)
- Congyang Zheng
- Wei Shi (ORCID: https://orcid.org/0009-0004-5305-4130)
- Xianlin Wang
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Dalian University of Technology (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Chinese PLA General Hospital (CN)
- Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1186/s13020-024-00980-4
- Citations
- 8
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.92
Funders
- Natural Science Foundation of Beijing Municipality