AB019. Detailed analysis of DNA hydroxymethylation observed with the malignant progression of IDH-mutant gliomas
This study elucidates the importance of region-specific DNA hydroxymethylation in the MP of IDH-mt astrocytomas, suggesting its potential impact on gene expression relevant to cancer malignancy. Our findings propose a complex interplay between hydroxymethylation and gene regulation, which may offer new insights into the mechanisms driving glioma progression and highlight potential targets for therapeutic intervention.
Authors
- Hiroyuki Aburatani (ORCID: https://orcid.org/0000-0003-0438-1544)
- Taijun Hana (ORCID: https://orcid.org/0000-0001-7649-3305)
- Erika Yamazawa (ORCID: https://orcid.org/0000-0002-3079-2331)
- Masashi Nomura (ORCID: https://orcid.org/0000-0001-6095-7849)
- Yoshihiro Kushihara (ORCID: https://orcid.org/0000-0001-6285-8967)
- Akitake Mukasa (ORCID: https://orcid.org/0000-0001-7776-9086)
- Genta Nagae (ORCID: https://orcid.org/0000-0002-2929-7990)
- Shiro Fukuda (ORCID: https://orcid.org/0000-0002-0065-662X)
- Yosuke Kitagawa (ORCID: https://orcid.org/0000-0002-1903-1283)
- Nobuhito Saito (ORCID: https://orcid.org/0000-0001-9756-781X)
- Takahide Nejo (ORCID: https://orcid.org/0000-0002-9191-8823)
- Tsukasa Koike (ORCID: https://orcid.org/0000-0002-9931-0716)
- Hirokazu Takami (ORCID: https://orcid.org/0000-0001-9742-7462)
- Satoshi Takahashi (ORCID: https://orcid.org/0000-0003-1506-9222)
- Kenji Tatsuno (ORCID: https://orcid.org/0000-0002-3046-3941)
- Shogo Yamamoto (ORCID: https://orcid.org/0000-0002-5564-2567)
- Shota Tanaka (ORCID: https://orcid.org/0000-0002-1426-4520)
- Takayoshi Umeda
- Hiroki Ueda (ORCID: https://orcid.org/0000-0001-9135-7117)
- Shunsaku Takayanagi
Institutions
- The University of Tokyo (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Chinese Clinical Oncology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.21037/cco-24-ab019
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00