Biomarkers in Pediatric Hemophagocytic Lymphohistiocytosis With Central Nervous System Involvement: A Cohort Study
CSF IFN-γ, sCD25, IL-10, IL-18, and CXCL9 levels were significantly higher in HLH patients with CNS involvement than those without and could predict HLH patients with CNS involvement. CSF CXCL9 might be a more sensitive biomarker to CNS-HLH than IFN-γ, while CSF IL-6 does not seem to play a vital role.
Authors
- Wenxin Ou (ORCID: https://orcid.org/0000-0001-9929-5619)
- Ang Wei (ORCID: https://orcid.org/0000-0002-7046-2417)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-3727-1192)
- Zhigang Li (ORCID: https://orcid.org/0000-0001-5086-5334)
- Qing Zhang (ORCID: https://orcid.org/0000-0001-6871-3435)
- Yunze Zhao
- Dong Wang (ORCID: https://orcid.org/0000-0002-8340-2763)
- Liping Zhang (ORCID: https://orcid.org/0000-0002-4628-2950)
- Hongyun Lian (ORCID: https://orcid.org/0009-0005-2413-8084)
- Tianyou Wang (ORCID: https://orcid.org/0000-0003-1355-0661)
- Honghao Ma
Institutions
- Capital Medical University (CN)
- Endocrinology Research Center (RU)
- Center for Children (US)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Journal of Pediatric Hematology/Oncology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1097/mph.0000000000002937
- Citations
- 2
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91