Levels of Plasma Endothelin-1, Circulating Endothelial Cells, Endothelial Progenitor Cells, and Cytokines after Cardiopulmonary Bypass in Children with Congenital Heart Disease: Role of Endothelin-1 Regulation
Congenital heart disease (CHD) can be complicated by pulmonary arterial hypertension (PAH). Cardiopulmonary bypass (CPB) for corrective surgery may cause endothelial dysfunction, involving endothelin-1 (ET-1), circulating endothelial cells (CECs), and endothelial progenitor cells (EPCs). These markers can gauge disease severity, but their levels in children's peripheral blood still lack consensus for prognostic value. The aim of our study was to investigate changes in ET-1, cytokines, and the absolute numbers (Ɲ) of CECs and EPCs in children 24 h before and 48 h after CPB surgery to identify high-risk patients of complications. A cohort of 56 children was included: 41 cases with CHD-PAH (22 with high pulmonary flow and 19 with low pulmonary flow) and 15 control cases. We observed that Ɲ-CECs increased in both CHD groups and that Ɲ-EPCs decreased in the immediate post-surgical period, and there was a strong negative correlation between ET-1 and CEC before surgery, along with significant changes in ET-1, IL8, IL6, and CEC levels. Our findings support the understanding of endothelial cell precursors' role in endogenous repair and contribute to knowledge about endothelial dysfunction in CHD.
Authors
- María Eugenia Paniagua-Medina (ORCID: https://orcid.org/0000-0002-5307-1625)
- Dina Villanueva‐García (ORCID: https://orcid.org/0000-0002-3910-809X)
- Angélica Rangel-López (ORCID: https://orcid.org/0000-0001-7040-9379)
- Miguel Lozano-Ramírez
- Horacio Márquez-González (ORCID: https://orcid.org/0000-0001-9041-5813)
- Juan José Pérez-Barragán
- Juan Carlos Núñez-Enríquez (ORCID: https://orcid.org/0000-0002-8070-9727)
- Ramón Paniagua (ORCID: https://orcid.org/0000-0003-3577-9707)
- José Arellano‐Galindo (ORCID: https://orcid.org/0000-0001-7289-0821)
- Lourdes Arriaga‐Pizano (ORCID: https://orcid.org/0000-0003-4433-2106)
- Abraham Majluf‐Cruz (ORCID: https://orcid.org/0000-0002-7697-5790)
- Dulce María López-Sánchez (ORCID: https://orcid.org/0000-0002-7318-0618)
- Sergio Zavala-Vega (ORCID: https://orcid.org/0000-0002-3010-4543)
- Ricardo López-Romero (ORCID: https://orcid.org/0000-0002-5030-5836)
- Héctor Jaime González-Cabello
- Minerva Mata‐Rocha (ORCID: https://orcid.org/0000-0003-0949-461X)
- Juan Manuel Mejía‐Aranguré (ORCID: https://orcid.org/0000-0001-8027-6231)
Institutions
- Mexican Social Security Institute (MX)
- Secretaria de Salud (MX)
- Hospital Infantil de México Federico Gómez (MX)
- Instituto Nacional de Enfermedades Respiratorias (MX)
- National Institute of Genomic Medicine (MX)
- Hospital de Especialidades (MX)
- Instituto Nacional de Neurología y Neurocirugía (MX)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3390/ijms25168895
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84