Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study
In this cross-sectional study of healthy middle-aged adults, detectable changes in brain imaging and clinical features were associated with remote, even mild, TBI in the general population. The potential contribution of vascular injury to TBI-related neurodegeneration presents promising avenues to identify potential targets, with findings highlighting the need to reduce TBI through early intervention and prevention in both clinical care and policymaking.
Authors
- Ivan Koychev (ORCID: https://orcid.org/0000-0001-6813-8493)
- Robert B. Dudas (ORCID: https://orcid.org/0000-0001-6151-2630)
- John T. O’Brien (ORCID: https://orcid.org/0000-0002-0837-5080)
- Natalie Jenkins (ORCID: https://orcid.org/0000-0002-1462-4733)
- Clare E. Mackay (ORCID: https://orcid.org/0000-0001-6111-8318)
- William Stewart (ORCID: https://orcid.org/0000-0003-2199-2582)
- Vanessa Raymont (ORCID: https://orcid.org/0000-0001-8238-4279)
- Paresh Malhotra (ORCID: https://orcid.org/0000-0002-1897-0780)
- Craig Ritchie (ORCID: https://orcid.org/0000-0002-6202-6906)
- Siobhan Coleman
- Elizabeth McKiernan (ORCID: https://orcid.org/0000-0001-7076-8216)
- Li Su (ORCID: https://orcid.org/0000-0003-0919-3462)
- Tony Thayanandan (ORCID: https://orcid.org/0000-0001-9470-5404)
- Stephen F. Carter (ORCID: https://orcid.org/0000-0002-9080-519X)
- Elijah Mak (ORCID: https://orcid.org/0000-0002-6437-8024)
- James D. Stefaniak (ORCID: https://orcid.org/0000-0002-1362-0538)
- Maria A Prats‐Sedano (ORCID: https://orcid.org/0000-0003-0209-9131)
- Sarah Gregory (ORCID: https://orcid.org/0000-0001-9864-8240)
- Maria‐Eleni Dounavi (ORCID: https://orcid.org/0000-0001-8287-346X)
- Audrey Low (ORCID: https://orcid.org/0000-0002-2520-454X)
- Graciela Muñiz‐Terrera (ORCID: https://orcid.org/0000-0002-4516-0337)
- Peter Swann
- Karen A. Ritchie (ORCID: https://orcid.org/0000-0002-0688-8982)
- Lorina Naçi (ORCID: https://orcid.org/0000-0001-9630-3978)
- Li Su (ORCID: https://orcid.org/0000-0002-6347-3986)
- Hannah Darwin
- Feng Deng (ORCID: https://orcid.org/0000-0002-8596-1518)
- Guy Williams
- Leo Chouliaras
Institutions
- Imperial College Healthcare NHS Trust (GB)
- Inserm (FR)
- Trinity College Dublin (IE)
- University of Cambridge (GB)
- University of Oxford (GB)
- Dementia UK (GB)
- Cambridgeshire and Peterborough NHS Foundation Trust (GB)
- Queen Elizabeth University Hospital (GB)
- University of Glasgow (GB)
- University of Sheffield (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.26774
- Citations
- 3
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Alzheimer's Association
- Eli Lilly and Company
- Biogen
- Osteopathic Heritage Foundation
- Wellcome Trust
- Alzheimer's Society
- TauRx Pharmaceuticals
- National Institute for Health and Care Research
- Eisai
- Novo Nordisk
- Dementias Platform UK
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre
- Cilag