Breast Cancer Index in Premenopausal Women With Early-Stage Hormone Receptor–Positive Breast Cancer
In this prospective-retrospective translational study of patients enrolled in SOFT, BCI was confirmed as prognostic in premenopausal women with HR+ breast cancer. The benefit from OFS-containing adjuvant endocrine therapy was greater for patients with BCI(H/I)-low tumors than BCI(H/I)-high tumors. BCI(H/I)-low status may identify premenopausal patients who are likely to benefit from this more intensive endocrine therapy.
Authors
- Catherine A. Schnabel (ORCID: https://orcid.org/0009-0006-5500-9290)
- Patrick Neven (ORCID: https://orcid.org/0000-0002-1434-9460)
- Marion van Mackelenbergh (ORCID: https://orcid.org/0000-0002-1084-5897)
- Sherene Loi (ORCID: https://orcid.org/0000-0001-6137-9171)
- Meredith M. Regan (ORCID: https://orcid.org/0000-0002-2428-6109)
- Wolfram Jochum (ORCID: https://orcid.org/0000-0001-6170-2020)
- Bettina Müller (ORCID: https://orcid.org/0000-0002-8589-5725)
- Robert E. Coleman (ORCID: https://orcid.org/0000-0002-1551-9871)
- Prudence A. Francis (ORCID: https://orcid.org/0000-0002-7207-9286)
- Khalil Zaman
- Antônio Bernardo (ORCID: https://orcid.org/0000-0002-2751-2626)
- Federica Villa (ORCID: https://orcid.org/0009-0005-5052-1079)
- Nancy E. Davidson (ORCID: https://orcid.org/0000-0003-1520-6442)
- Gini F. Fleming (ORCID: https://orcid.org/0000-0003-2845-4023)
- Carlo Tondini (ORCID: https://orcid.org/0000-0003-0635-8954)
- Ruth O’Regan
- Roswitha Kammler (ORCID: https://orcid.org/0000-0002-5572-7894)
- Marco Colleoni (ORCID: https://orcid.org/0000-0002-5743-3013)
- Kai Treuner (ORCID: https://orcid.org/0009-0006-3443-3578)
- Hervé Bonnefoi (ORCID: https://orcid.org/0000-0003-4293-9748)
- Katarzyna J. Jerzak (ORCID: https://orcid.org/0000-0002-3995-0308)
- Patrizia Dell’Orto (ORCID: https://orcid.org/0000-0001-9166-0829)
- Charles E. Geyer (ORCID: https://orcid.org/0000-0002-2379-5702)
- Eva Ciruelos (ORCID: https://orcid.org/0000-0002-2796-1042)
- James N. Ingle (ORCID: https://orcid.org/0000-0003-1257-7731)
- Per Karlsson (ORCID: https://orcid.org/0000-0003-4841-2672)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-2657-4876)
- Meritxell Bellet
- Giuseppe Viale
- István Láng
- Silvana Martino
Institutions
- Sunnybrook Health Science Centre (CA)
- Mayo Clinic (US)
- Harvard University (US)
- Institute of Cancer Research (GB)
- Université de Bordeaux (FR)
- Inserm (FR)
- The University of Melbourne (AU)
- University of Toronto (CA)
- University of Washington (US)
- Alliance for Clinical Trials in Oncology (US)
- Kantonsspital St. Gallen (CH)
- Universitair Ziekenhuis Leuven (BE)
- Peter MacCallum Cancer Centre (AU)
- Weston Park Cancer Centre (GB)
- Research Institute Hospital 12 de Octubre (ES)
- St Vincent's Hospital Melbourne (AU)
- University of Chicago Medical Center (US)
- Fred Hutch Cancer Center (US)
- Istituti Clinici Scientifici Maugeri (IT)
- Breast Cancer Trials (AU)
- ECOG-ACRIN Cancer Research Group (US)
- Cancer Trials Australia (AU)
- Angeles Clinic and Research Institute (US)
- Ospedale Papa Giovanni XXIII (IT)
- University Hospital Schleswig-Holstein (DE)
- Alessandro Manzoni Hospital (IT)
- Biothera (United States) (US)
- Dana-Farber Cancer Institute (US)
- Hologic (United States) (US)
- Breast Center (CH)
- European Organisation for Research and Treatment of Cancer (BE)
- Vall d'Hebron Hospital Universitari (ES)
- UPMC Hillman Cancer Center (US)
- German Breast group (DE)
- Institut Bergonié (FR)
- University of Pittsburgh Medical Center (US)
- Swiss Group For Clinical Cancer Research (CH)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- International Breast Cancer Study Group (CH)
- NRG Oncology (US)
- NSABP Foundation (US)
- SWOG Cancer Research Network (US)
- Vall d'Hebron Institute of Oncology (ES)
- BoRdeaux Institute of onCology (FR)
- University of Rochester (US)
- National Cancer Research Institute (GB)
- European Institute of Oncology (IT)
- University of Newcastle Australia (AU)
- University of Gothenburg (SE)
- University of Lübeck (DE)
- KU Leuven (BE)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1001/jamaoncol.2024.3044
- Citations
- 8
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.28