Nickel-Catalyzed Desulfurative Cross-Coupling of Aryl Iodides with Heteroaromatic Thioethers via C–S Bond Cleavage
Herein, we present a Ni-catalyzed direct cross-coupling of heteroaromatic thioethers with aryl iodides via selective C(sp<sup>2</sup>)-S bond cleavage under reductive conditions, thereby providing various biaryl frameworks with high efficiency. Mechanistic studies suggested Mo(CO)<sub>6</sub> played a crucial role in facilitating the activation of the C(sp<sup>2</sup>)-S bond. This protocol demonstrated a wide substrate scope, operational simplicity, and good functional group compatibility. Furthermore, the utility of this reaction was highlighted by facile scale-up and sequential modification of heteroaryl frameworks.
Authors
- Pingliang Zhu
- Xinjin Li (ORCID: https://orcid.org/0000-0002-8406-4372)
- Fenggang Sun (ORCID: https://orcid.org/0000-0001-9366-6087)
- Hui Liu
- Yu Zhao (ORCID: https://orcid.org/0009-0001-0162-2595)
- Baolong Xu
- Shaowen Ling
Institutions
- Shandong University of Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1021/acs.joc.4c00678
- Citations
- 2
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province