Copper(I) Iodide-Catalyzed Perfluoroalkoxylation Reaction of Alkyl Halides
We report an efficient perfluoroalkoxylation reaction of alkyl halides catalyzed by copper(I) iodide (CuI), which facilitates the simultaneous activation of both perfluoroalkoxide and alkyl halides. This methodology is tolerant of a wide range of functional groups and eliminates the need for costly metal reagents. The reaction is conducted in a single step under mildly practical conditions.
Authors
- Fanhong Wu
- Wangchuan Xiao
- Bingjun Le
- Jingjing Wu (ORCID: https://orcid.org/0000-0002-5733-7670)
- Chao Liu (ORCID: https://orcid.org/0000-0003-1968-031X)
- Xiaoyu Ma (ORCID: https://orcid.org/0000-0003-1085-4002)
- Xiong Wu
Institutions
- Jingdong (China) (CN)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
- Shanghai Institute of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1021/acs.orglett.4c02428
- Citations
- 3
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.62
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Institute of Technology