Inflammatory plasma profile in genetic symptomatic and presymptomatic Frontotemporal Dementia − A GENFI study
We showed that inflammatory proteins are upregulated in MAPT and GRN SMC, with some specific factors altered in GRN only, whereas no changes were seen in C9ORF72 carriers. Notably, only IL-1α levels were decreased in both SMC and PMC, independent of the type of causal mutation, suggesting common modifications occurring in the preclinical phase of the disease.
Authors
- John Cornelis Van Swieten (ORCID: https://orcid.org/0000-0001-6278-6844)
- Manuela Pintus (ORCID: https://orcid.org/0000-0003-1994-2682)
- Sandro Sorbi (ORCID: https://orcid.org/0000-0002-0380-6670)
- Caroline Graff (ORCID: https://orcid.org/0000-0002-9949-2951)
- Andrea Arighi (ORCID: https://orcid.org/0000-0003-2865-3970)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- James B. Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Alexander Gerhard (ORCID: https://orcid.org/0000-0002-8071-6062)
- Christopher Butler (ORCID: https://orcid.org/0000-0002-7502-9284)
- María Serpente (ORCID: https://orcid.org/0000-0003-0725-1403)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Alexandre de Mendonça (ORCID: https://orcid.org/0000-0002-0488-1453)
- Eve Ferry‐Bolder
- Laura Ghezzi (ORCID: https://orcid.org/0000-0001-8180-9730)
- Isabelle Le Ber (ORCID: https://orcid.org/0000-0002-2508-5181)
- Marina Arcaro (ORCID: https://orcid.org/0000-0002-3821-0682)
- Raquel Sánchez‐Valle (ORCID: https://orcid.org/0000-0001-7750-896X)
- Harro Seelaar (ORCID: https://orcid.org/0000-0003-1989-7527)
- Pietro Tiraboschi (ORCID: https://orcid.org/0000-0002-2171-1720)
- Phoebe H. Foster (ORCID: https://orcid.org/0000-0001-6300-6598)
- Florence Pasquier (ORCID: https://orcid.org/0000-0001-9880-9788)
- Arabella Bouzigues (ORCID: https://orcid.org/0000-0002-0267-8590)
- Lize C. Jiskoot (ORCID: https://orcid.org/0000-0002-1120-1858)
- Vittoria Borracci (ORCID: https://orcid.org/0009-0006-7406-376X)
- Lucy L. Russell
- Jonathan D. Rohrer (ORCID: https://orcid.org/0000-0002-6155-8417)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Elizabeth Finger (ORCID: https://orcid.org/0000-0003-4461-7427)
- Luca Sacchi (ORCID: https://orcid.org/0000-0002-3929-9009)
- Chiara Fenoglio (ORCID: https://orcid.org/0000-0001-6332-4721)
- Daniela Galimberti (ORCID: https://orcid.org/0000-0002-9284-5953)
- Emanuela Rotondo (ORCID: https://orcid.org/0000-0001-6134-9407)
- Fermín Moreno (ORCID: https://orcid.org/0000-0001-5200-3164)
- Tiziana Carandini (ORCID: https://orcid.org/0000-0002-0568-7580)
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
- Rik Vandenberghe
- Mario Masellis
- Robert Laforce
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
- Isabel Santana
Institutions
- Western University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Centre National de la Recherche Scientifique (FR)
- Sunnybrook Health Science Centre (CA)
- Karolinska University Hospital (SE)
- University of Lisbon (PT)
- Inserm (FR)
- University of Toronto (CA)
- Universität Ulm (DE)
- Université de Lille (FR)
- University of Cambridge (GB)
- Douglas Mental Health University Institute (CA)
- Health Sciences Centre (CA)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Biogipuzkoa Health Research Institute (ES)
- MRC Brain Network Dynamics Unit (GB)
- Occupational Cancer Research Centre (CA)
- Munich Cluster for Systems Neurology (DE)
- Don Carlo Gnocchi Foundation (IT)
- Essen University Hospital (DE)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Hertie Institute for Clinical Brain Research (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Université Laval (CA)
- University College London (GB)
- University of Coimbra (PT)
- University of Brescia (IT)
- Ludwig-Maximilians-Universität München (DE)
- Erasmus University Rotterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1016/j.bbi.2024.08.030
- Citations
- 9
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 3.32
Funders
- Erasmus Medisch Centrum
- KU Leuven
- Karolinska Institutet
- Ludwig-Maximilians-Universität München
- Universidade de Coimbra
- Universidade de Lisboa
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Medical Research Council