Gamma-glutamyl transferase secreted by Helicobacter pylori promotes the development of gastric cancer by affecting the energy metabolism and histone methylation status of gastric epithelial cells
H. pylori secreted GGT decreased the expression of glutamine and α-KG in gastric epithelial cells, increased the expression of histones H3K9me3 and H3K27me3, and activated the Wnt signaling pathway through RPL15 expression, ultimately changing the biological characteristics of the gastric epithelium and promoting the occurrence of gastric cancer. Altered energy metabolism and histone hypermethylation are important factors involved in this process.
Authors
- Mengke Fan (ORCID: https://orcid.org/0000-0002-9194-5709)
- Huiying Shi (ORCID: https://orcid.org/0000-0002-0796-9944)
- Rong Lin (ORCID: https://orcid.org/0000-0001-9463-8942)
- Zeyu Wang (ORCID: https://orcid.org/0000-0003-0087-8123)
- Weijun Wang (ORCID: https://orcid.org/0000-0001-6907-2561)
- Lingjun Meng (ORCID: https://orcid.org/0000-0003-2359-1555)
- Xin Jiang (ORCID: https://orcid.org/0000-0001-7007-0483)
- Suya Pang
- Zhe Wang (ORCID: https://orcid.org/0009-0002-3397-0938)
Institutions
- Union Hospital (HK)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1186/s12964-024-01780-x
- Citations
- 8
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.58
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- National Key Research and Development Program of China