Copper overload exacerbates testicular aging mediated by lncRNA:CR43306 deficiency through ferroptosis in Drosophila
Testicular aging manifests as impaired spermatogenesis and morphological alterations in Drosophila. Nonetheless, the comprehensive molecular regulatory framework remains largely undisclosed. This investigation illustrates the impact of copper overload on testicular aging and underscores the interplay between copper overload and lncRNA. Copper overload triggers Cuproptosis through the mitochondrial TCA cycle, facilitating intracellular interactions with Ferroptosis, thereby governing testicular aging. Dysfunction of lncRNA:CR43306 also contributes to testicular aging in Drosophila, emphasizing the significance of lncRNA:CR43306 as a novel aging-associated lncRNA. Moreover, copper overload exacerbates spermatid differentiation defects mediated by lncRNA:CR43306 deficiency through oxidative stress, copper, and iron transport. Therapeutically, Ferrostatin-1 and Resveratrol emerge as potential remedies for addressing testicular aging. This study offers perspectives on the regulatory mechanisms involving copper overload and lncRNA:CR43306 deficiency in the context of testicular aging.
Authors
- Zi-Yu Cao (ORCID: https://orcid.org/0000-0002-4225-1583)
- Xinda Wang (ORCID: https://orcid.org/0000-0002-2735-2490)
- Ziyue Pan (ORCID: https://orcid.org/0000-0003-2367-262X)
- Ying Zheng (ORCID: https://orcid.org/0000-0003-2723-9022)
- Jiaxin Li (ORCID: https://orcid.org/0000-0001-5699-3820)
- Xuhui Zeng (ORCID: https://orcid.org/0000-0002-5936-4699)
- Yiheng Liu (ORCID: https://orcid.org/0000-0002-7778-2368)
- Bo Zheng (ORCID: https://orcid.org/0000-0002-1496-0753)
- Qiuru Huang
- Cong Shen (ORCID: https://orcid.org/0000-0002-9982-176X)
- Qingqing Hu (ORCID: https://orcid.org/0000-0003-2820-9490)
- Yujuan Qi (ORCID: https://orcid.org/0000-0002-0098-6813)
- Xiaolin Bi (ORCID: https://orcid.org/0000-0002-7172-7851)
- Jingqi Huang
- Jun Yu (ORCID: https://orcid.org/0000-0003-3109-4102)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-2789-0811)
- Xuxin He
- Chenyu Wang (ORCID: https://orcid.org/0009-0000-2936-6610)
- Qiushi Xia
- Guoqing Han
Institutions
- Xuzhou Medical College (CN)
- Nantong University (CN)
- Suzhou Municipal Hospital (CN)
- Xuzhou Central Hospital (CN)
- Yangzhou University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1016/j.redox.2024.103315
- Citations
- 16
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Zhejiang University
- ShanghaiTech University