B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-Catalyzed Multicomponent Reactions of 2,3-Diketoesters, Amines, Allenes, and Nucleophiles: Synthesis of 2α-Functionalized Pyrroles
An efficient B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-catalyzed multicomponent reaction of 2,3-diketoesters, amines, allenes, and nucleophiles was reported, which afforded 2α-functionalized pyrroles in moderate to good yields. The reaction features low catalyst loading, usage of a small amount of solvent, high atom economy, tunable installation of diverse functional groups at 2α-position, and water being formed as the byproduct. This is the first multicomponent reaction that combines vicinal tricarbonyl compounds with allenes.
Authors
- Qiang Sha (ORCID: https://orcid.org/0000-0002-3253-2226)
- Weiwei Zhang (ORCID: https://orcid.org/0000-0002-6077-1443)
Institutions
- Nanjing Agricultural University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1021/acs.joc.4c01221
- Citations
- 3
- Primary Topic
- Synthesis and Characterization of Pyrroles
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Foundation Research Project of Jiangsu Province